'College GameDay' picks for Week games, including Texas-Tennessee

For the fourth consecutive week, ESPN's "College GameDay" is heading to SEC Country as Nick Saban, Pat McAfee and Co. preview the biggest college football matchups on the Week 4 slate.

This week's stop takes the show to Rocky Top, where Texas quarterback Arch Manning will make his first trip to Neyland Stadium for the Longhorns' SEC opener against Tennessee. The setting carries extra significance for Manning, whose uncle, Pro Football Hall of Fame quarterback Peyton Manning , cemented his legacy with the Volunteers before embarking on his NFL career.

The top-ranked Longhorns and the 13th-ranked Volunteers are slated for a noon ET kickoff inside Neyland Stadium in Knoxville.

Trinidad Chambliss and No. 6 Mississippi look to keep their momentum going after last week's statement win over Lane Kiffin and LSU with a trip to Gainesville for a matchup with Florida . One thing to watch for on Saturday will be the status of Rebels' running back Kewan Lacy , whose availability could play a significant role in Ole Miss ' offensive game plan.

Speaking of LSU , Sam Leavitt and the 11th-ranked Tigers look to bounce back at home against Texas A&M. The Tigers have won eight of their last nine games at home, with the lone defeat coming against the Aggies last season, a loss that got Brian Kelly fired.

Other notable games on Saturday include Oklahoma's trip to No. 2 Georgia , a Big Ten clash between No. 17 Iowa and No. 18 Michigan that could feature plenty of punts and field-position battles, a quarterback matchup between Austin Simmons and Kamario Taylor as Missouri visits Mississippi State and Oregon 's road test against Southern California in Los Angeles.

Here's a look at how "College GameDay" picks each of the marquee Week 2 matchups on Saturday:

'College GameDay' picks, predictions for Week 4

Johnny Knoxville (Guest Picker): Georgia

Johnny Knoxville (Guest Picker): Ole Miss

Johnny Knoxville (Guest Picker): Michigan

Johnny Knoxville (Guest Picker): Alabama

Johnny Knoxville (Guest Picker): Texas A&M

Johnny Knoxville (Guest Picker): Missouri

Johnny Knoxville (Guest Picker): Western Michigan

Johnny Knoxville (Guest Picker): West Virginia

Kirk Herbstreit: Didn't pick; calling the game

Johnny Knoxville (Guest Picker): Tennessee

Be sure to check out USA TODAY Sports' new College Football Unfiltered podcast , hosted by USA TODAY Sports columnist Blake Toppmeyer. You can stream on YouTube or download via Apple podcasts and Spotify .

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