Thursday Night Football: How to watch the Detroit Lions vs. Buffalo Bills game tonight

This week's Thursday Night Football matchup will be the first regular season game played at the new Highmark Stadium in Orchard Park, New York; the Buffalo Bills picked up a win on the road against the Houston Texans in Week 1 and now they'll see how their home turf treats them when they host the Detroit Lions in Week 2. The Lions also had a successful first week, narrowly winning against the New Orleans Saints 31-30 in overtime. Here's a look at all of last week's results .

Here's how you can watch this week's Lions vs. Bills Thursday Night Football game, and check out the full Week 2 schedule.

How to watch the Detroit Lions vs. Buffalo Bills:

Detroit Lions vs. Buffalo Bills game time:

The Lions vs. Bills game kicks off at 8:15 p.m. ET/5:20 p.m. PT this Thursday, Sept. 17, 2026.

Detroit Lions vs. Buffalo Bills game channel:

The Week 2 game between the Lions and Bills will stream on Prime Video.

How to watch the Detroit Lions vs. Buffalo Bills game without cable:

Detroit Lions vs. Buffalo Bills: 8:15 p.m. ET (Prime Video)

Carolina Panthers vs. Atlanta Falcons : 1 p.m. ET (FOX)

Minnesota Vikings vs. Chicago Bears : 1 p.m. ET ( FOX )

New Orleans Saints vs. Baltimore Ravens : 1 p.m. ET ( CBS )

Cincinnati Bengals vs. Houston Texans: 1 p.m. ET ( CBS )

Green Bay Packers vs. NY Jets : 1 p.m. ET ( FOX )

Jacksonville Jaguars vs. Denver Broncos : 4:05 p.m. ET ( CBS )

Las Vegas Raiders vs. L.A. Chargers : 4:05 p.m. ET ( CBS )

Seattle Seahawks vs. Arizona Cardinals : 4:25 p.m. ET ( FOX )

Indianapolis Colts vs. Kansas City Chiefs : 8:20 p.m. ET (NBC/Peacock)

NY Giants vs. L.A. Rams : 8:15 p.m. ET ( ESPN/ABC )

To recap, here are all the ways we recommend watching NFL games in 2026.