49ers WR Deebo Samuel leaves Seahawks game with hamstring injury in another injury blow to offense

The San Francisco 49ers are down another key offensive weapon.

Wide receiver Deebo Samuel left Sunday's game against the Seattle Seahawks with a hamstring injury in the second half and was quickly ruled out for the rest of the game.

The injury took place in the third quarter as Samuel ran around the edge on a first-down play. As he collapsed, he dropped the ball and fell prone on the field.

It was a frightening moment as Samuel's condition wasn't initially clear. He was able to eventually stand up and limp off the field.

But he clearly wasn't right and clutched his right thigh as he made his way to the sideline. The 49ers announced minutes later that he'd been ruled out of the game with a hamstring injury.

The 49ers also lost wide receiver Jacob Cowing to an ankle injury and listed him as questionable to return.

This is a team that's been beset with injuries at wide receiver since training camp. Starter Ricky Pearsall is out for the season after undergoing preseason surgery to repair a damaged PCL. Standout rookie De'Zhaun Stribling is expected to miss roughly 10 weeks with an ankle injury suffered in San Francisco's Week 1 win over the Los Angeles Rams in Australia .

Demarcus Robinson is on injured reserve with a high-ankle sprain sustained in Week 2's win over the Miami Dolphins . Christian Kirk has been on injured reserve since the preseason with a lingering calf injury.

No. 1 receiver Mike Evans, meanwhile, is playing and thriving through a rib injury he sustained in Week 3 against the Arizona Cardinals.

The 49ers entered Sunday's game at 4-0 despite the injuries and will have to cotinue to play hobbled and shorthanded on offense.