Lamar Jackson ruled out of Bills-Ravens game with thumb injury sustained on Baltimore's first offensive play

Ravens quarterback Lamar Jackson left Sunday's game against the Buffalo Bills with a right thumb injury sustained on Baltimore's first offensive play from scrimmage.

The Ravens quickly ruled him out for the rest of the game.

Jackson took contact on his hand after a pass and was in immediate pain. He left the field and walked straight to the locker room. Backup Tyler Huntley took his place at quarterback.

The Ravens initially announced that Jackson was questionable to return with a thumb injury before ruling him out before the conclusion of the first quarter. The injury is to the thumb on his throwing hand.

Jackson, a two-time NFL MVP, was playing in his first game since sustaining a high-ankle sprain in Week 4 that caused him to miss three games. He returned to the 4-3 Ravens in time for the critical AFC showdown against Josh Allen and the Bills, but now he's out against the Bills and potentially for longer.

The injury is another difficult blow for Jackson and a Ravens team seeking to compete for a Super Bowl championship. Jackson is one of the game's best players when healthy, but injuries have derailed his last two seasons.

Jackson missed four games last season and was limited in several others with leg and back injuries. The Ravens were projected last season as a Super Bowl contender but finished 8-9 and missed the playoffs.

The Ravens again were projected to compete for a Super Bowl this season, but Jackson is now potentially looking at a long-term absence. Jackson, 29, is playing on the fourth year of a five-year, $260 million contract.

Team owner Steve Bisciotti has expressed his desire to make Jackson a Raven for life, but the two sides reportedly haven't engaged in substantial contract negotiations .