5 Chargers storylines to watch in season opener against the Cardinals

The Chargers will kick off their 2026 NFL regular season at home against the Cardinals on Sunday, September 13, 2026, at 1:25 PM PT.

Here are the five major storylines to track during the season opener:

The most anticipated offseason storyline culminates in Mike McDaniel's regular-season debut as the Chargers ' new offensive coordinator. McDaniel is tasked with importing his explosive, motion-heavy passing concepts and marrying them with Justin Herbert 's elite arm talent. For the past two seasons under Jim Harbaugh, the Chargers operated with a more traditional, run-heavy identity. How McDaniel sequences his play calls, uses pre-snap motion to isolate defenders, and pushes the ball downfield with Herbert will dictate this offense's ceiling. Additionally, McDaniel is instilling a revamped ground game built around a wide-zone blocking scheme in hopes of maximizing sophomore running back Omarion Hampton .

A rebuilt, healthy offensive line still facing interior questions

The Chargers enter the season with a sigh of relief as their tackle tandem of Rashawn Slater and Joe Alt are completely healthy after both missed significant time with injuries last year. Their presence gives Herbert premium protection against the Cardinals ' edge rushers, highlighted by Josh Sweat , but the interior of the line remains a major focal point. Kayode Awosika , who was named the starting left guard over Trey Pipkins III, will line up directly next to second-round rookie Jake Slaughter. Slaughter was thrust into the starting center role following a season-ending injury to veteran Tyler Biadasz . Compounding this new-look interior is veteran right guard Cole Strange , who arrived in free agency via a two-year, $13 million contract to reunite with McDaniel. Strange's consistency faced scrutiny from fans during the preseason. How seamlessly Awosika, Slaughter, and Strange gel as a brand-new interior unit will be absolutely vital.

After former defensive coordinator Jesse Minter left to become the Ravens ' head coach, the Chargers opted for familiarity by bringing back former safeties coach Chris O'Leary to lead the defense after serving as Western Michigan's defensive coordinator in 2025. Under Minter, Los Angeles boasted one of the NFL's best scoring defenses over the last two seasons. O'Leary's challenge in Week 1 is to prove that the unit won't suffer much of a drop-off. While the core remains intact, I am watching closely to see how effective O'Leary's more aggressive blitz approach and distinct coverage variations are against Cardinals quarterback Jacoby Brissett .

The Chargers' defense took a hit late in training camp when veteran linebacker Denzel Perryman was placed on injured reserve. On the unofficial depth chart, Del'Shawn Phillips is the starter alongside Daiyan Henley . Phillips has historically been a special teams ace and a rotational depth piece. While Phillips is listed as the starter, I'm curious whether this will be more of a rotation, with Troy Dye and summer standout Marlowe Wax also seeing the field to determine who gets the majority of playing time.

Much of the offseason chatter revolved around how the Chargers' pass-catchers would fit into McDaniel's scheme. Out wide, all eyes are on how targets will be split between Ladd McConkey , Quentin Johnston , and Tre' Harris. At tight end, rookie standout Oronde Gadsden II was listed as the third-string tight end behind Charlie Kolar and David Njoku , suggesting the coaching staff is prioritizing blocking and traditional inline skill sets. Herbert's target distribution will offer the first real blueprint for who he establishes a rapport with.